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Imlunestrant - Eli Lilly and Company/Loxo-Oncology

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Drug Profile

Imlunestrant - Eli Lilly and Company/Loxo-Oncology

Alternative Names: IMULURIO; Inluriyo; LY-3484356

Latest Information Update: 11 Feb 2026

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At a glance

  • Originator Eli Lilly and Company
  • Class Antineoplastics; Azetidines; Benzopyrans; Fluorinated hydrocarbons; Heterocyclic compounds with 4 or more rings; Phenyl ethers; Quinolines; Small molecules
  • Mechanism of Action Estrogen receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed HER2 negative breast cancer
  • Phase I Endometrial cancer

Most Recent Events

  • 22 Dec 2025 Registered for HER2-negative-breast-cancer (Second-line therapy or greater, Inoperable/Unresectable, Monotherapy) in Japan (PO)
  • 17 Dec 2025 Eli Lilly and company plans phase II PreEMBER trial in HER2-negative-breast-cancer (Metastatic disease) in Belgium, US, France, Germany, Italy (PO), in December 2025 (NCT07287098)
  • 12 Dec 2025 Efficacy data from a phase III EMBER-3 trial in HER2-negative-breast-cancer released by Eli Lilly and Company

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