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KPI 012

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Drug Profile

KPI 012

Alternative Names: CMB 012; KPI-012

Latest Information Update: 12 Mar 2026

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At a glance

  • Originator Combangio Inc
  • Developer KALA BIO
  • Class Collagens; Eye disorder therapies; Growth factors; Nerve growth factors; Peptide hydrolases; Proteins
  • Mechanism of Action Collagen replacements; Intracellular signaling peptides and protein replacements; Peptide hydrolase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Corneal injuries
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Corneal injuries; Limbal stem cell deficiency; Retinitis pigmentosa; Sjogren's syndrome; Stargardt disease

Most Recent Events

  • 04 Mar 2026 KALA BIO in-licenses researgency AI platform technology from Younet AI
  • 20 Oct 2025 Kala Pharmaceuticals terminates phase II clinical trials in Corneal injuries in US, Puerto Rico and Argentina (Ophthalmic), due to lack of efficacy (NCT05727878)
  • 29 Sep 2025 Discontinued - Phase-I for Corneal injuries in Mexico (Ophthalmic)

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