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LXE 408

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Drug Profile

LXE 408

Alternative Names: LXE-408

Latest Information Update: 03 Jun 2025

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At a glance

  • Originator Novartis
  • Developer Drugs for Neglected Diseases Initiative Foundation; Novartis
  • Class Amides; Antiparasitics; Antiprotozoals; Fluorobenzenes; Oxazoles; Pyrimidines; Small molecules; Triazoles
  • Mechanism of Action Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chagas disease; Visceral leishmaniasis

Most Recent Events

  • 30 May 2025 Drugs for Neglected Diseases plans a phase II trial for Cutaneous Leishmaniasis in Brazil and Panama in November 2025 (PO) (NCT06997159)
  • 28 Apr 2025 Phase-II clinical trials in Chagas disease in Argentina, Colombia (PO) (NCT06632600)
  • 07 Oct 2024 Novartis plans a phase II trial for Chagas disease (PO) in August 2025 (NCT06632600)

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