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Emiltatug ledadotin - Day One Biopharmaceuticals

Drug Profile

Emiltatug ledadotin - Day One Biopharmaceuticals

Alternative Names: B7-H4 ADC - Mersana Therapeutics; B7-H4 targeting antibody drug conjugate - Mersana Therapeutics; DAY-501; Emi-Le; XMT-1660

Latest Information Update: 25 Aug 2026

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At a glance

  • Originator Mersana Therapeutics
  • Class Antibodies; Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 02 Jun 2026 Interim efficacy data from a phase I/II trial in Adenoid cystic carcinoma presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
  • 01 Jun 2026 Updated efficacy and adverse events data from a phase I/II trial in Adenoid cystic carcinoma released by Day One Biopharmaceuticals
  • 01 Jun 2026 Day One Biopharmaceuticals plans a pivotal phase II trial for Adenoid cystic carcinoma

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