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PL 9643

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Drug Profile

PL 9643

Alternative Names: PL-9643

Latest Information Update: 14 May 2025

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At a glance

  • Originator Palatin Technologies
  • Class Anti-inflammatories; Eye disorder therapies; Peptides
  • Mechanism of Action Melanocortin type 1 receptor agonists; Melanocortin type 5 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Dry eyes
  • Preclinical Diabetic retinopathy; Retinal disorders

Most Recent Events

  • 29 Apr 2025 Palatin Technologies plans a phase III MELODY-2 in Dry eyes in the second half of 2025 (Ophthalmic)
  • 29 Apr 2025 Palatin Technologies plans a phase III MELODY-3 trials in Dry eyes in the second half of 2025(Ophthalmic)
  • 28 Aug 2024 Palatin Technologies concluded a positive Type C meeting with the FDA and agreement on the two phase III MELODY-2 and MELODY-3 trials protocols, including the sign and symptom endpoints for PL 9643 for Dry eye disease (DED)

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