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Cambritaxestat - iOnctura

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Drug Profile

Cambritaxestat - iOnctura

Alternative Names: IOA-289

Latest Information Update: 04 Oct 2024

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At a glance

  • Originator Cancer Research Technology; Merck & Co
  • Developer iOnctura
  • Class Antifibrotics; Antineoplastics; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Cell proliferation inhibitors; ENPP2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Pancreatic cancer
  • Phase I Solid tumours
  • Preclinical Non-alcoholic steatohepatitis

Most Recent Events

  • 04 Oct 2024 Cambritaxestat is still in phase-I development in Solid-tumours (In volunteers) in Italy (PO, Capsule) (NCT05027568)
  • 31 May 2024 Efficacy and adverse event data from a phase I/II trial in Pancreatic cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 07 Mar 2024 Cambritaxestat receives Orphan Drug status for Pancreatic cancer in USA

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