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Encaleret - BridgeBio Pharma

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Drug Profile

Encaleret - BridgeBio Pharma

Alternative Names: BBP-305; CLTX-305; Encaleret Sulfate

Latest Information Update: 05 Mar 2026

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At a glance

  • Originator Calcilytix therapeutix
  • Developer BridgeBio Pharma; Calcilytix Therapeutics
  • Class Amines; Benzoic acids; Calcium regulators; Ethers; Halogenated hydrocarbons; Osteoporosis therapies; Small molecules
  • Mechanism of Action Calcium-sensing receptor antagonists; Parathyroid hormone receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypocalcaemia; Hypoparathyroidism
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hypocalcaemia; Hypoparathyroidism

Most Recent Events

  • 25 Feb 2026 BridgeBio announced intention to launch encalret in late 2026/early 2027
  • 14 Jan 2026 Phase-II/III clinical trials in Hypocalcaemia (In children, In infants, In neonates, In adolescents, Treatment-experienced) in USA (PO) (NCT07080385)
  • 12 Jan 2026 BridgeBio completes End-of-phase II meeting with the US FDA

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