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Developer
Beijing CC-Pharming; iBio Inc; Texas A&M University
Class
Synthetic vaccines; Viral vaccines; Virus-like particle vaccines
Mechanism of Action
Immunostimulants
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
No
New Molecular Entity
No
Highest Development Phases
Preclinical
COVID 2019 infections
Most Recent Events
09 Apr 2020
iBio signs a Memorandum of Understanding with the Infectious Disease Research Institute for IBIO 200
26 Mar 2020
Preclinical trials in COVID-2019 infections (Prevention) in USA (unspecified route)
26 Mar 2020
iBio plans clinical development for COVID-2019 infections
Development Overview
Introduction
IBIO 200 is a virus-like particle (VLP) based vaccine being developed by iBio and Beijing CC Pharming using iBio's FastPharming System™, for the prevention of COVID-2019 infections. The vaccine is designed to maximise uptake by antigen presenting cells in order to increase the overall immune response. A SARS-CoV-2 derived antigen is fused to a self-assembling protein partner to generate the VLP. The antigen is displayed in a repetitive structure and geometry, and the particle is decorated with oligomannose molecules to resemble the structure of a naturally occurring virus.FastPharming System™ combines vertical farming, automated hydroponics, and glycan engineering technologies wherein plants are used as bioreactors for development of vaccines and biologics. Preclinical development is underway in the US. Early research is underway in China.
Company Agreements
In February 2020, iBio and Beijing CC Pharming entered into a collaboration to develop and test a new coronavirus vaccine to be manufactured using iBio’s FastPharming System™. Financial terms of the deal are undisclosed.[1][2]
In April 2020,iBio signed a Memorandum of Understanding (MOU) with the Infectious Disease Research Institute (IDRI) to support iBio’s SARS-CoV-2 Virus-Like Particle (VLP) vaccine development. The MOU calls for iBio and IDRI to establish a separate, additional agreement within the next 60 days if iBio opts to include one of IDRI’s adjuvants in the COVID-19 vaccine development programme (IBIO 200). The MoU integrates IDRI into iBio’s collaboration with the Texas A&M University System to create a strong partnership that brings deep experience and advanced technologies and capabilities to the task of moving IBIO 200 into the clinic.[3]
In June 2016, Texas A&M University System entered into a development agreement with iBio for collaborative program in plant-produced pharmaceuticals. The collaboration will use the research and development resources of TAMUS with the commercial therapeutics and vaccine development and manufacturing capabilities of iBio.[4]
Key Development Milestones
In March 2020, iBio initiated preclinical studies of IBIO 200 at the Texas A&M University System (“TAMUS”) laboratories as part of the Master Joint Development Agreement established between iBio and TAMUS[5].
As of February 2020, plant based coronavirus vaccine is in early research for the treatment of COVID-2019 infections[1].
Patent Information
In March 2020, iBio filed four provisional patent applications number US9 012 199 with the U.S. Patent and Trademark Office (US PTO), for Virus Like Particle (VLP) platform technology and lichenase carrier immunostimulatory (“LickM”) adjuvant technology. The applications also cover vaccine manufacturing method using FastPharming system™[6].
Drug Properties & Chemical Synopsis
Formulation
Injection
Class
Synthetic vaccines, Viral vaccines, Virus-like particle vaccines
iBio signs a Memorandum of Understanding with the Infectious Disease Research Institute for IBIO 200 [3]
Updated 15 Apr 2020
26 Mar 2020
Phase Change - Preclinical
Preclinical trials in COVID-2019 infections (Prevention) in USA (unspecified route) [5]
Updated 01 Apr 2020
26 Mar 2020
Trial Update
iBio plans clinical development for COVID-2019 infections [5]
Updated 01 Apr 2020
11 Mar 2020
Patent Information
iBio files for patent protection with the US PTO for Virus Like Particle (VLP) platform technology and lichenase carrier immunostimulatory (LickM) adjuvant technology for development of COVID-2019 vaccines in USA [6]
Updated 14 Aug 2020
11 Feb 2020
Phase Change
Early research in COVID-2019-infections (Prevention) in USA (unspecified route)
Updated 11 Feb 2020
06 Feb 2020
Phase Change
Early research in COVID-2019-infections (Prevention) in China (unspecified route) [1]
Updated 11 Feb 2020
03 Feb 2020
Licensing Status
iBio and Beijing CC Pharming agree to co-develop coronavirus vaccine for COVID-2019 infections [1]
Updated 14 Aug 2020
13 Jun 2016
Licensing Status
iBio and Texas A&M University agree co-develop vaccines [4]
Updated 01 Apr 2020
References
iBio and CC-Pharming Initiate Joint Development of Coronavirus Vaccine.
