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FXR 314

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Drug Profile

FXR 314

Alternative Names: FXR-314; MET-642

Latest Information Update: 07 Apr 2025

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At a glance

  • Originator Metacrine
  • Developer Metacrine; Organovo Holdings
  • Class Amides; Anti-inflammatories; Benzene derivatives; Cyclohexanes; Cyclopropanes; Hepatoprotectants; Pyrazoles; Small molecules
  • Mechanism of Action Farnesoid X-activated receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Liver disorders

Highest Development Phases

  • Phase II Non-alcoholic steatohepatitis
  • Phase I Hepatic fibrosis; Inflammatory bowel diseases
  • Preclinical Gastroenteritis

Most Recent Events

  • 25 Mar 2025 Eli Lilly and Company acquires FXR 314 from Organovo Holdings
  • 25 Feb 2025 Organovo’s FXR Program, including FXR 314, to Be acquired by Eli Lilly and Company
  • 06 Jan 2025 Pharmacodynamics data from a preclinical trial in Inflammatory bowel disease released by Organovo Holdings

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