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CB 03

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Drug Profile

CB 03

Alternative Names: CB-003 - Zhimeng Biopharma; CB-03; CB03-154

Latest Information Update: 17 Sep 2025

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At a glance

  • Originator Zhimeng Biopharma
  • Class Analgesics; Antidepressants; Antiepileptic drugs; Small molecules
  • Mechanism of Action KCNQ2 potassium channel stimulants; KCNQ3 potassium channel stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Amyotrophic lateral sclerosis
  • Phase II Epilepsy; Major depressive disorder
  • Phase I Bipolar disorders
  • Preclinical Stroke
  • No development reported Pain

Most Recent Events

  • 11 Sep 2025 NMPA approves IND application for CB-03 in Epilepsy
  • 11 Sep 2025 Zhimeng Biopharma plans a phase-II trial for Epilepsy (Adjunctive therapy) in China (PO), (NCT06612775)
  • 19 Aug 2025 Phase-I clinical trials in Bipolar disorders (unspecified route) prior to August 2025 (Zhimeng Biopharma pipeline, August 2025)

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