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DNL 343

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Drug Profile

DNL 343

Alternative Names: DNL-343

Latest Information Update: 28 Jan 2025

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At a glance

  • Originator Denali Therapeutics Inc
  • Class Acetamides; Antidementias; Cyclobutanes; Ethers; Oxadiazoles; Small molecules
  • Mechanism of Action Eukaryotic initiation factor 2b stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Amyotrophic lateral sclerosis
  • Preclinical Ataxia
  • No development reported Dementia; Unspecified

Most Recent Events

  • 28 Jan 2025 No recent reports of development identified for phase-I development in Amyotrophic-lateral-sclerosis(In volunteers) in United Kingdom (PO)
  • 06 Jan 2025 Efficacy and adverse events data from the phase II/III HEALEY ALS Platform trial in Amyotrophic lateral sclerosis released by Denali Therapeutics
  • 06 Jan 2025 Chemical structure information added.

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