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Givastomig - I-MAB Biopharma

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Drug Profile

Givastomig - I-MAB Biopharma

Alternative Names: ABL-111; CD4B; Giva; TJ-033721; TJ-CD4B; TJ-CLDN4B

Latest Information Update: 23 Sep 2024

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At a glance

  • Originator I-MAB Biopharma
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD137 antigen agonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Adenocarcinoma; Gastric cancer; Pancreatic cancer; Solid tumours
  • No development reported Colorectal cancer

Most Recent Events

  • 23 Sep 2024 Updated efficacy, adverse events and PK data from a phase I trial in Solid-tumours released by I-Mab Biopharma
  • 13 Sep 2024 Pharmacokinetics, efficacy and adverse events data from the phase I trial in Solid tumours presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)
  • 04 Sep 2024 Phase-I development in Solid-tumours (Late-stage disease, Metastatic disease) in USA (Parenteral) (NCT04900818)

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