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DNL 593

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Drug Profile

DNL 593

Alternative Names: DNL-593; PTV progranulin - Denali Therapeutics; PTV:PGRN; TAK-594

Latest Information Update: 11 Jan 2024

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At a glance

  • Originator Denali Therapeutics Inc
  • Developer Denali Therapeutics Inc; Takeda
  • Class Antidementias; Recombinant fusion proteins; Recombinant proteins
  • Mechanism of Action Progranulin protein replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Frontotemporal dementia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Frontotemporal dementia

Most Recent Events

  • 09 Jan 2024 Efficacy data from a phase I/II trial in Frontotemporal dementia released by Denali Therapeutics
  • 31 Dec 2023 DNL 593 receives Orphan Drug status for Frontotemporal dementia (Takeda pipeline, May 2024)
  • 16 Jul 2023 Interim pharmacokinetic and adverse events data from a phase I/II trial in Frontotemporal dementia presented at Alzheimer's Association International Conference 2023 (AAIC-2023)

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