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Drug Profile

Icalcaprant - Cerevel Therapeutics

Alternative Names: ABBV-1354; CVL-354; Kappa opiate antagonist - Cerevel therapeutics

Latest Information Update: 18 Feb 2025

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At a glance

  • Originator Pfizer
  • Developer Cerevel Therapeutics
  • Class Antidepressants; Drug withdrawal therapies; Small molecules
  • Mechanism of Action Opioid kappa receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Opioid-related disorders
  • No development reported Major depressive disorder; Substance-related disorders

Most Recent Events

  • 17 Jan 2025 AbbVie completes a phase I 528 Asian PK trial for Healthy volunteers in USA (PO) (NCT06722417)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Major depressive disorder(In volunteers, In adults) in USA (PO, Suspension)
  • 26 Nov 2024 AbbVie initiates a phase I 528 Asian PK trial for Healthy volunteers in USA (PO) (NCT06722417)

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