Anti-COVID-19 dimeric antigen receptor T-cell therapy - Sorrento Therapeutics
Alternative Names: Anti-COVID-19 DAR-T-cell therapy - Sorrento Therapeutics; Anti-COVID-2019 DAR-T-cell therapy - Sorrento TherapeuticsLatest Information Update: 28 Mar 2024
At a glance
- Originator Sorrento Therapeutics
- Class Antivirals; Cell therapies; Fab fragments; Gene therapies
- Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
-
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- No development reported COVID 2019 infections
Most Recent Events
- 28 Mar 2024 No recent reports of development identified for preclinical development in COVID-2019-infections in USA (Parenteral)
- 31 Mar 2020 Sorrento Therapeutics enters into a research agreement with University of Texas Medical Branch for preclinical testing for COVID-2019 therapeutics
- 27 Feb 2020 Preclinical trials in COVID-2019-infections in USA (Parenteral)
Development Overview
Introduction
Anti-COVID-19 dimeric antigen receptor T (DAR-T) cell therapy is being developed by Sorrento Therapeutics for the treatment of COVID-2019 infection. The cell therapy is based on the company's proprietary non-viral vector Knock out/knock in (KOKI) technology and is derived from the G-MAB antibody library. Preclinical development is underway in the US.
Sorrento Therapeutics believes that the KOKI DAR-T technology offers a number of advantages over virus based technology's including site-specific integration, enhanced clonal expansion and a streamlined transgene construct production. By using healthy donor T cells, the technology avoids reliance on the patient’s T cells, thus avoiding treatment delays and supporting reduced manufacturing costs ultimately overcoming some drawbacks of the CAR-T therapy. In DAR-T therapy, Sorrento Therapeutics has incorporated fab fragments in the construct, instead of ScFV.
As at March 2024, no recent reports of development had been identified for preclinical development in COVID-2019-infections in USA (Parenteral).
Company Agreements
In March 2020, Sorrento Therapeutics entered into a research testing agreement with the University of Texas Medical Branch at Galveston for the preclinical testing of Sorrento’s COVID-19 therapeutic product candidates. The testing will be performed at the University of Texas Medical Branch where most recently a COVID-19 viral isolate was obtained and the infection cell model for the SARS-CoV-2 virus was established. University of Texas Medical Branch will be advancing Sorrento’s proprietary COVID-19 product candidates. [1]
Key Development Milestones
Preclinical development is underway in the US [2] .
Patent Information
Sorrento Therapeutics has filed a patent application no. WO 2019 173 837A1 covering ‘Dimeric antigen receptors (DAR)’ [3] .
Drug Properties & Chemical Synopsis
- Route of administration Parenteral
- Formulation unspecified
- Class Antivirals, Cell therapies, Fab fragments, Gene therapies
- Target T lymphocyte
- Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
-
WHO ATC code
V03A-X (Other therapeutic products)
-
EPhMRA code
V3X (All Other Therapeutic Products)
Development Status
Summary Table
Indication | Qualifier | Patient Segment | Phase | Countries | Route / Formulation | Developers | Event Date |
---|---|---|---|---|---|---|---|
COVID 2019 infections | - | - | No development reported (Preclinical) | USA | Parenteral / unspecified | Sorrento Therapeutics | 28 Mar 2024 |
Commercial Information
Involved Organisations
Organisation | Involvement | Countries |
---|---|---|
Sorrento Therapeutics | Originator | USA |
Sorrento Therapeutics | Owner | USA |
University of Texas Medical Branch | Collaborator | USA |
Development History
Event Date | Update Type | Comment |
---|---|---|
28 Mar 2024 | Phase Change - No development reported | No recent reports of development identified for preclinical development in COVID-2019-infections in USA (Parenteral) Updated 28 Mar 2024 |
31 Mar 2020 | Licensing Status | Sorrento Therapeutics enters into a research agreement with University of Texas Medical Branch for preclinical testing for COVID-2019 therapeutics [1] Updated 07 Apr 2020 |
27 Feb 2020 | Phase Change - Preclinical | Preclinical trials in COVID-2019-infections in USA (Parenteral) [2] Updated 12 Mar 2020 |
27 Feb 2020 | Trial Update | Sorrento Therapeutics plans a clinical trial for COVID-2019 infections in USA [2] Updated 12 Mar 2020 |
11 Mar 2019 | Patent Information | Sorrento Therapeutics files for patent protection for dimeric antigen receptors [3] Updated 12 Mar 2020 |
References
-
SORRENTO AND THE UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON ENTER INTO PRECLINICAL TESTING AGREEMENT FOR COVID-19 THERAPEUTIC CANDIDATES.
Media Release -
Sorrento to Provide Corporate Update, Including DAR-T Cell Therapy Advances, at LEERINK Global Healthcare Conference.
Media Release -
Dimeric antigen receptors (dar) patent. Internet-Doc 2020;.
Available from: URL: https://patents.google.com/patent/WO2019173837A1/en
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