Drug Profile

PLN 1474

Alternative Names: PLN-1474

Latest Information Update: 28 May 2025

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At a glance

Originator Pliant Therapeutics
Developer Novartis; Pliant Therapeutics
Class 1 ring heterocyclic compounds; Amides; Amines; Antifibrotics; Hepatoprotectants; Naphthyridines; Nonanoic acids; Small molecules
Mechanism of Action Integrin alphavbeta1 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

No development reported Hepatic fibrosis

Most Recent Events

28 May 2025 No recent reports of development identified for phase-I development in Hepatic-fibrosis(In volunteers) in USA (PO)
17 Aug 2023 Chemical structure information added
30 Apr 2023 PLN 1474 is still in phase-I development in Hepatic-fibrosis(In volunteers) in USA (PO) (Pliant Therapeutics pipeline, April 2023)

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