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Research programme: polymerase theta inhibitors - IDEAYA Biosciences/GlaxoSmithKline

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Drug Profile

Research programme: polymerase theta inhibitors - IDEAYA Biosciences/GlaxoSmithKline

Alternative Names: DNA polymerase θ inhibitors; Pol theta; Pol-theta - IDEAYA Biosciences; POLQ inhibitors; Synthetic lethality programme - IDEAYA Biosciences

Latest Information Update: 28 Dec 2023

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At a glance

  • Originator IDEAYA Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action DNA-directed DNA polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • No development reported Solid tumours

Most Recent Events

  • 28 Dec 2023 No recent reports of development identified for preclinical development in Solid-tumours in USA
  • 29 Aug 2022 IDEAYA plans a first-in-human phase I trial of Pol Theta programme for Solid tumours (Combination therapy) in 1H of 2023
  • 10 Jan 2022 IDEAYA Biosciences plans IND-enabling studies for Pol Theta Helicase programme in the first half of 2022

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