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Estradiol/norethisterone acetate/relugolix - Sumitomo Pharma America

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Drug Profile

Estradiol/norethisterone acetate/relugolix - Sumitomo Pharma America

Alternative Names: E2/NETA; Estradiol/norethindrone acetate/relugolix - Sumitomo Pharma America; Low-dose hormonal add-back; MYFEMBREE; Relugolix combination tablet; Relugolix/estradiol hemihydrate/norethisterone acetate; RYEQO

Latest Information Update: 29 May 2026

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At a glance

  • Originator Myovant Sciences
  • Developer ASKA Pharmaceutical; Pfizer; Sumitomo Pharma America; Takeda
  • Class Analgesics; Antineoplastics; Contraceptives; Estrenes; Fluorobenzenes; Norpregnenes; Pyridazines; Pyrimidines; Small molecules; Thiophenes; Urea compounds
  • Mechanism of Action Estrogen receptor agonists; LHRH receptor antagonists; Progesterone receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Pain; Uterine leiomyoma
  • Phase III Pregnancy

Most Recent Events

  • 31 Mar 2026 Myovant Sciences completes the phase III SERENE trial in Pregnancy (In adults, Prevention) in USA (PO) (NCT04756037)
  • 05 Jun 2025 Knight Therapeutics in-licenses Estradiol/norethindrone acetate/relugolix from Sumitomo Pharma America in Canada
  • 31 May 2024 ASKA Pharmaceutical in-licenses relugolix combination tablet from Takeda in Endometriosis in Japan

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