Drug Profile

Tonlamarsen - Ionis Pharmaceuticals

Alternative Names: AGT-2.5-L_Rx; ION-904; Tonlamarsen sodium

Latest Information Update: 19 May 2026

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At a glance

Originator Ionis Pharmaceuticals
Class Antihypertensives; Antihypotensives; Antisense oligonucleotides
Mechanism of Action Angiotensinogen expression inhibitors; Gene silencing

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes
Available For Licensing Yes

Highest Development Phases

Phase II Hypertension

Most Recent Events

06 May 2026 Phase-II clinical trials in Hypertension in Canada (SC) (NCT07511361)
06 May 2026 Kardigan initiates enrolment in the phase IIb KARDINAL-ASH trial for Hypertension in the US (SC) (NCT07511361)
29 Mar 2026 Efficacy and adverse events data from a phase II trial in Hypertension released by Ionis Pharmaceuticals

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