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Tonlamarsen - Ionis Pharmaceuticals

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Drug Profile

Tonlamarsen - Ionis Pharmaceuticals

Alternative Names: AGT-2.5-LRx; ION-904; Tonlamarsen sodium

Latest Information Update: 09 Apr 2026

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At a glance

  • Originator Ionis Pharmaceuticals
  • Class Antihypertensives; Antihypotensives; Antisense oligonucleotides
  • Mechanism of Action Angiotensinogen expression inhibitors; Gene silencing
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Hypertension

Most Recent Events

  • 29 Mar 2026 Efficacy and adverse events data from a phase II trial in Hypertension released by Ionis Pharmaceuticals
  • 28 Mar 2026 Kardigan plans a phase IIb KARDINAL-ASH trial for Hypertension in USA (SC, Injection) (NCT07511361)
  • 17 Mar 2026 Kardigan completes a phase II KARDINAL trial in Hypertension (Treatment-resistant) in USA (SC) (NCT06864104)

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