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Tonlamarsen - Ionis Pharmaceuticals

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Drug Profile

Tonlamarsen - Ionis Pharmaceuticals

Alternative Names: AGT-2.5-LRx; ION-904; Tonlamarsen sodium

Latest Information Update: 25 Mar 2025

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At a glance

  • Originator Ionis Pharmaceuticals
  • Class Antihypertensives; Antihypotensives; Antisense oligonucleotides
  • Mechanism of Action Angiotensinogen expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Hypertension

Most Recent Events

  • 13 Mar 2025 Ionis Pharmaceuticals initiates a phase II trial in Hypertension (Treatment-resistant) in USA (SC) (NCT06864104)
  • 28 Mar 2024 No recent reports of development identified for phase-I development in Hypertension(In volunteers) in Canada (SC, Injection)
  • 11 Nov 2023 Efficacy and adverse events data from a phase I trial in Hypertension presented at the American Heart Association Scientific Sessions 2023 (AHA-2023)

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