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ION 464

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Drug Profile

ION 464

Alternative Names: BIIB-101; ION-464; IONIS-BIIB6Rx

Latest Information Update: 28 Jul 2023

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer Biogen; Ionis Pharmaceuticals
  • Class Antiparkinsonians; Antisense oligonucleotides; Neuroprotectants
  • Mechanism of Action Alpha-synuclein inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Parkinson's disease
  • Phase I/II Multiple system atrophy

Most Recent Events

  • 28 Jul 2023 No recent reports of development identified for phase-I development in Multiple system atrophy(In the elderly, In adults) in Austria (Intrathecal, Injection)
  • 21 Jul 2022 Phase-I clinical trials in Multiple system atrophy (In the elderly, In adults) in France (Intrathecal) (NCT04165486)
  • 21 Jul 2022 Phase-I clinical trials in Multiple system atrophy (In the elderly, In adults) in Germany (Intrathecal) (NCT04165486)

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