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JR 446

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Drug Profile

JR 446

Alternative Names: JR-446

Latest Information Update: 15 May 2025

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At a glance

  • Originator JCR Pharmaceuticals
  • Class Enzymes
  • Mechanism of Action Alpha N acetyl D glucosaminidase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mucopolysaccharidosis III
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Mucopolysaccharidosis III

Most Recent Events

  • 15 May 2025 JR 446 receives Orphan Drug status for Mucopolysaccharidosis III in USA
  • 05 Dec 2024 Phase-I/II clinical trials in Mucopolysaccharidosis III (In neonates, In infants, In children, In adolescents) in Japan (IV) (NCT06488924)
  • 05 Jul 2024 JCR Pharmaceuticals plans a I/II clinical trial for Mucopolysaccharidosis III (In children, In adolescents) in Japan in August 2024 (IV,infusion)

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