Drug Profile

Tebapivat - Agios Pharmaceuticals

Alternative Names: AG 946

Latest Information Update: 11 Jun 2025

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At a glance

Originator Agios Pharmaceuticals
Class Antianaemics; Small molecules
Mechanism of Action Pyruvate kinase stimulants

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Myelodysplastic syndromes
New Molecular Entity Yes

Highest Development Phases

Phase II Anaemia; Sickle cell anaemia

Most Recent Events

01 May 2025 Phase-II clinical trials in Sickle cell anaemia in USA (PO) (NCT06924970)
01 May 2025 Agios plans to initiate a phase II clinical trial for Sickle cell disease(PO) in mid-2025.
21 Feb 2025 Agios Pharmaceuticals completes a phase I bioavailability trial (In volunteers) in USA (PO, capsule) (NCT06745271)

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