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Migaldendranib - Ashvattha Therapeutics

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Drug Profile

Migaldendranib - Ashvattha Therapeutics

Alternative Names: D-4517; D-4517.2; HD-sunitinib analog

Latest Information Update: 14 May 2025

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At a glance

  • Originator Ashvattha Therapeutics
  • Class Anti-inflammatories; Drug conjugates; Eye disorder therapies
  • Mechanism of Action Angiogenesis inhibitors; Colony-stimulating factor receptor antagonists; Fms-like tyrosine kinase 3 inhibitors; Platelet-derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor modulators; Proto-oncogene protein c-kit inhibitors; Proto-oncogene protein c-ret inhibitors; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists; Vascular endothelial growth factor receptor-3 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diabetic macular oedema; Wet age-related macular degeneration
  • No development reported Diabetic retinopathy

Most Recent Events

  • 07 May 2025 Interim adverse events and efficacy data from the phase-II TEJAS trial in Wet age-related macular degeneration and Diabetic macular oedema released by Ashvattha Therapeutics
  • 28 Feb 2025 No recent reports of development identified for phase-I development in Diabetic-macular-oedema(In volunteers) in Australia (SC, Injection)
  • 28 Feb 2025 No recent reports of development identified for phase-I development in Wet age-related macular degeneration(In volunteers) in Australia (SC, Injection)

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