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CHS 114

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Drug Profile

CHS 114

Alternative Names: CHS-114; SRF-114

Latest Information Update: 07 May 2025

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At a glance

  • Originator Vaccinex
  • Developer Coherus BioSciences; Surface Oncology
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CCR8 receptor antagonists; Regulatory T-lymphocyte inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 28 Apr 2025 Efficacy and adverse event data from phase I trial in in Solid tumours released by Coherus Biosciences
  • 01 Apr 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Combination therapy, Inoperable/Unresectable) in USA (IV) (NCT06657144)
  • 03 Dec 2024 Coherus Biosciences plans a phase Ib trial in Head and neck cancer and Gastric cancer (Combination therapy, Second-line therapy or greater) (Infusion), in Q1 2025

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