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IDE 397

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Drug Profile

IDE 397

Alternative Names: GSK-4362676; IDE-397

Latest Information Update: 17 Sep 2025

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At a glance

  • Originator IDEAYA Biosciences
  • Developer Amgen; IDEAYA Biosciences
  • Class Antineoplastics; Small molecules
  • Mechanism of Action MAT2A protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Bladder cancer; Gastric cancer; Non-small cell lung cancer; Oesophageal cancer
  • Phase I/II Solid tumours; Urogenital cancer

Most Recent Events

  • 17 Sep 2025 Phase-I/II clinical trials in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Taiwan, Spain, South Korea, Denmark (PO) (NCT05975073)
  • 08 Sep 2025 Efficacy and adverse event data from a phase I/II trial in Solid tumours released by IDEAYA Biosciences
  • 25 Apr 2025 Pharmacodynamics data from preclinical studies in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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