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IMA 401

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Drug Profile

IMA 401

Alternative Names: IMA-401; IMA401 MAGEA4/8; IMA401 TCER™; MAGE A4/8 TCER

Latest Information Update: 28 Nov 2025

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At a glance

  • Originator immatics biotechnologies GmbH
  • Developer Immatics N.V.
  • Class Antineoplastics; Immunoglobulin fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 28 Nov 2025 Phase-I clinical trials in Solid tumours (Monotherapy, Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) is underway in Germany (NCT05359445)
  • 17 Nov 2025 Immatics plans a clinical trial for Non-small cell lung cancer (Combination Therapy)(IV)
  • 12 Nov 2025 Updated efficacy and adverse event data from a phase Ia/II trial in Solid tumours released by Immatic

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