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AWAKE LM TT

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Drug Profile

AWAKE LM TT

Alternative Names: Awake 101; Awake 102; Awake 103; AWAKE-LM-TT; Listeria tetanus toxoid; Listeria TT; Lm LLO TT

Latest Information Update: 01 Jul 2026

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At a glance

  • Originator Loki Therapeutics
  • Developer Loki Therapeutics; Matter Bio
  • Class Antineoplastics; Bacterial antigens; Bacterial toxins; Immunotherapies
  • Mechanism of Action T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Preclinical Adenocarcinoma; Glioblastoma; Ovarian cancer
  • Research Breast cancer; Colorectal cancer; Liver cancer; Lung cancer

Most Recent Events

  • 01 Jul 2026 AWAKE LM TT is still in preclinical phase for Ovarian cancer in USA (Loki therapeutics pipeline, July 2026)
  • 01 Jul 2026 Preclinical trials in Glioblastoma in USA (Parenteral) prior to July 2026 (Matter Bio pipeline, July 2026)
  • 10 Jun 2026 US FDA approves IND application for LM LLO TT in Adenocarcinoma

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