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ZF 874

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Drug Profile

ZF 874

Alternative Names: ZF-874

Latest Information Update: 17 Aug 2022

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At a glance

  • Originator University of Cambridge
  • Developer Centessa Pharmaceuticals
  • Class Small molecules
  • Mechanism of Action Alpha 1-antitrypsin modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alpha 1-antitrypsin deficiency

Most Recent Events

  • 10 Aug 2022 Discontinued - Phase-I for Alpha 1-antitrypsin deficiency (In volunteers) in United Kingdom (PO) because of the adverse event results from the study which demonstrated elevated liver enzymes (AST/ALT) in a PiMZ patient dosed with 5 mg/kg BID
  • 30 Mar 2022 Updated pharmacokinetics data from a phase I trial in Alpha 1-antitrypsin deficiency released by Centessa Pharmaceuticals
  • 01 Nov 2021 Interim efficacy, adverse events, pharmacokinetics and pharmacodynamics data from a phase I trial in Alpha 1-antitrypsin deficiency released by Centessa Pharmaceuticals

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