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Divarasib - Genentech

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Drug Profile

Divarasib - Genentech

Alternative Names: GDC-6036; RG 6330; RO-7435846

Latest Information Update: 31 Aug 2026

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; Roche
  • Class Aminopyridines; Antineoplastics; Chlorinated hydrocarbons; Fluorine compounds; Ketones; Piperazines; Pyrrolidines; Quinazolines; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase I Breast cancer; Solid tumours

Most Recent Events

  • 24 Aug 2026 Genentech initiates an expanded-access programme for Non small cell lung cancer (Late-stage disease, Metastatic disease) (NCT07783009)
  • 05 Aug 2026 Roche intends to file regulatory application for Non-small cell lung cancer (Second-line therapy or greater) in 2026 (Roche pipeline, August 2026)
  • 13 Jul 2026 Efficacy and adverse event data from a phase III Krascendo 1 trial in Non-small cell lung cancer released by Roche

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