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Divarasib - Genentech

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Drug Profile

Divarasib - Genentech

Alternative Names: GDC-6036; RG 6330; RO-7435846

Latest Information Update: 13 Aug 2024

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At a glance

  • Originator Genentech
  • Developer Genentech; Roche
  • Class Aminopyridines; Antineoplastics; Chlorinated hydrocarbons; Fluorine compounds; Ketones; Piperazines; Pyrrolidines; Quinazolines
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase I Solid tumours

Most Recent Events

  • 02 Aug 2024 Phase-III clinical trials in Non-small cell lung cancer (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in South Korea (PO) (NCT06497556)
  • 11 Jul 2024 Roche plans a phase III Krascendo 1 trial for Non-small cell lung cancer (Metastatic disease, Second-line therapy or greater, Late-stage disease, Inoperable/Unresectable) in July 2025 (PO) (NCT06497556)
  • 09 May 2024 Roche intends to file regulatory application for Non-small cell lung cancer (Second-line therapy or greater) in or after 2027 (Roche pipeline, May 2024)

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