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ABL 103

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Drug Profile

ABL 103

Alternative Names: ABL-103

Latest Information Update: 24 Sep 2025

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At a glance

  • Originator ABL Bio; Handok Inc
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action CD137 antigen agonists; Immunomodulators; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 06 Aug 2025 Phase-I/II clinical trials in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater, Inoperable/Unresectable) in South Korea (IV) (NCT07158918)
  • 25 Apr 2025 Pharmacodynamics and adverse event data from a preclinical study in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 04 Oct 2024 ABL Bio and Merck Sharp and Dohme agree to co-develop ABL 103 for Solid tumours

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