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ENT 001

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Drug Profile

ENT 001

Alternative Names: ENT-001

Latest Information Update: 26 Sep 2025

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At a glance

  • Originator Ospedale San Raffaele
  • Developer Enthera
  • Class Anti-inflammatories; Antihyperglycaemics; Monoclonal antibodies
  • Mechanism of Action Insulin like growth factor binding protein 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Inflammatory bowel diseases; Type 1 diabetes mellitus

Most Recent Events

  • 26 Sep 2025 ENT 001 is still in phase I trials for Inflammatory bowel disease and Type 1 diabetes mellitus (In Volunteers) in Netherlands (IV, Infusion)
  • 23 Jan 2024 Topline pharmacokinetics and adverse events data from a phase-I trial in Inflammatory bowel diseases and Type 1 diabetes mellitus released by Enthera
  • 23 Jan 2024 Enthera initiates enrolment in a phase-Ib trial for Ulcerative colitis

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