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ITI 333

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Drug Profile

ITI 333

Alternative Names: ITI-333

Latest Information Update: 15 Apr 2025

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At a glance

  • Originator Intra-Cellular Therapies
  • Class Antidepressants; Antipsychotics; Anxiolytics; Drug withdrawal therapies; Mood stabilisers; Opioid analgesics; Small molecules
  • Mechanism of Action Dopamine D1 receptor antagonists; Opioid receptor agonists; Serotonin 5-HT2A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Anxiety disorders; Mood disorders; Pain; Substance-related disorders

Most Recent Events

  • 02 Apr 2025 Intra-Cellular Therapies has been acquired by Johnson & Johnson
  • 04 Mar 2025 ITI 333 is still in phase-I trials in Substance-related disorders (In volunteers) in USA (PO)
  • 31 Dec 2024 Discontinued - Phase-I for Substance-related disorders (In volunteers) in USA (PO), before December 2024 (Intra-Cellular Therapies pipeline, March 2025)

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