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LHP 588

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Drug Profile

LHP 588

Alternative Names: COR-588; LHP-588

Latest Information Update: 13 Mar 2025

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At a glance

  • Originator Cortexyme
  • Developer Lighthouse Pharmaceuticals; Quince Therapeutics
  • Class Antibacterials; Antidementias; Small molecules
  • Mechanism of Action Gingipain cysteine endopeptidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Alzheimer's disease; Periodontal disorders

Highest Development Phases

  • Phase II Alzheimer's disease
  • Clinical Phase Unknown Dementia
  • No development reported Periodontal disorders

Most Recent Events

  • 17 Feb 2025 Phase-II clinical trials in Alzheimer's disease in USA (PO) (NCT06847321)
  • 28 Sep 2024 No recent reports of development identified for phase-I development in Periodontal-disorders(In volunteers) in Australia (PO, Capsule)
  • 16 Nov 2023 USFDA approves IND application for LHP 588 in Alzheimer's disease

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