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APG 5918

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Drug Profile

APG 5918

Alternative Names: APG-5918; EEDi-5273

Latest Information Update: 14 May 2025

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At a glance

  • Originator University of Michigan
  • Developer Ascentage Pharma
  • Class Antianaemics; Antineoplastics; Small molecules
  • Mechanism of Action Polycomb repressive complex 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Anaemia; Haematological malignancies; Solid tumours
  • Preclinical Haemoglobinopathies

Most Recent Events

  • 28 Apr 2025 Pharmacodynamics data from a preclinical study in Prostate cancer released by Ascentage Pharma
  • 07 Dec 2024 Safety, pharmacokinetics and pharmacodynamics data from a preclinical studies in Haematological malignancies presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)
  • 13 Jun 2024 Pharmacodynamics data from a preclinical study in Anaemia presented at the 29th Congress of the European Haematology Association (EHA-2024)

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