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Allopregnanolone prodrug - Seaport Therapeutics

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Drug Profile

Allopregnanolone prodrug - Seaport Therapeutics

Alternative Names: Glyph Allopregnanolone; GlyphAllo; LYT-300; SPT-300

Latest Information Update: 07 Apr 2026

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At a glance

  • Originator Seaport Therapeutics
  • Developer PureTech Health; Seaport Therapeutics
  • Class Antidepressants; Anxiolytics; Small molecules
  • Mechanism of Action GABA A receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anxiety disorders; Major depressive disorder
  • No development reported Neurological disorders

Most Recent Events

  • 25 Mar 2026 Interim efficacy data from a phase IIa trial in Anxiety disorders released by Seaport Therapeutics
  • 02 Sep 2025 Seaport Therapeutics initiates a phase II trial for Major depressive disorder in USA, Bulgaria, Czech Republic, Germany, Poland, Slovakia (PO) (NCT07161700)
  • 14 Jul 2025 Phase-II clinical trials in Major depressive disorder in USA (PO) (NCT07065240)

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