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Lufotrelvir - Pfizer

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Drug Profile

Lufotrelvir - Pfizer

Alternative Names: PF-07304814

Latest Information Update: 20 Jan 2025

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At a glance

  • Originator Pfizer
  • Developer National Institute of Allergy and Infectious Diseases; Pfizer
  • Class Antivirals; Phosphates; Small molecules
  • Mechanism of Action Coronavirus 3C-like proteinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued COVID 2019 infections

Most Recent Events

  • 08 Sep 2024 Pharmacokinetics data from a phase I trial presented at the 2024 American College of Clinical Pharmacology Annual Meeting (ACCP-2024)
  • 24 Mar 2023 Pfizer and National Institute of Allergy and Infectious Diseases suspends the phase III Trial H6: PF-07304814 trial for COVID-2019 infections in USA and Denmark (IV), as the candidate is withdrawn from development by the manufacturer after being placed on clinical hold by the US FDA, prior to March 2023 (NCT05780541)
  • 08 Feb 2022 Discontinued - Phase-III for COVID-2019 infections in Denmark (IV)

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