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Zelebrudomide - Nurix

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Drug Profile

Zelebrudomide - Nurix

Alternative Names: NX-2127

Latest Information Update: 12 Dec 2024

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At a glance

  • Originator Nurix
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase degraders; IKZF1 protein degraders; IKZF3 protein degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 09 Dec 2024 Pharmacodynamics data from a preclinical studies in Chronic lymphocytic leukaemia released by Nurix Therapeutics
  • 11 Jul 2024 NX 2127 is still in phase I development in Chronic-lymphocytic-leukaemia (Late-stage disease, Second-line therapy or greater) in USA (PO) (NCT04830137)
  • 11 Jul 2024 NX 2127 is still in phase I development in Diffuse large B cell lymphoma(Late-stage disease, Second-line therapy or greater) in USA (PO) (NCT04830137)

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