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Rezatapopt - PMV Pharmaceuticals

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Drug Profile

Rezatapopt - PMV Pharmaceuticals

Alternative Names: PC-14586; PC-586

Latest Information Update: 30 Apr 2026

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At a glance

  • Originator PMV Pharmaceuticals
  • Developer M. D. Anderson Cancer Center; PMV Pharmaceuticals
  • Class Alkynes; Amines; Anisoles; Antineoplastics; Benzamides; Fluorinated hydrocarbons; Indoles; Piperidines; Small molecules
  • Mechanism of Action Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fallopian tube cancer; Peritoneal cancer; Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 22 Apr 2026 PMV Pharmaceuticals plans to submit NDA to the US FDA for Ovarian cancer (Second-line therapy or greater) in the first quarter of 2027
  • 02 Mar 2026 Rezatapopt - PMV Pharmaceuticals receives Orphan Drug status for Fallopian tube cancer in USA
  • 02 Mar 2026 Rezatapopt - PMV Pharmaceuticals receives Orphan Drug status for Ovarian cancer in USA

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