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Rezatapopt - PMV Pharmaceuticals

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Drug Profile

Rezatapopt - PMV Pharmaceuticals

Alternative Names: PC-14586; PC-586

Latest Information Update: 13 Jun 2025

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At a glance

  • Originator PMV Pharmaceuticals
  • Developer M. D. Anderson Cancer Center; PMV Pharmaceuticals
  • Class Alkynes; Amines; Anisoles; Antineoplastics; Benzamides; Fluorinated hydrocarbons; Indoles; Piperidines; Small molecules
  • Mechanism of Action Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 25 Apr 2025 Efficacy and adverse event data from the phase-I/II PYNNACLE trial in Solid tumours were presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 30 Jan 2025 Phase-I clinical trials in Acute myeloid leukaemia (Combination therapy) in USA (PO) (NCT06616636)
  • 30 Jan 2025 Phase-I clinical trials in Myelodysplastic syndromes (Combination therapy) in USA (PO) (NCT06616636)

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