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Tinlorafenib - Pfizer

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Drug Profile

Tinlorafenib - Pfizer

Alternative Names: AR00504461; ARRY 461; PF-07284890

Latest Information Update: 19 Apr 2024

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At a glance

  • Originator Pfizer
  • Class Amines; Antineoplastics; Chlorobenzenes; Fluorinated hydrocarbons; Quinazolines; Small molecules; Sulfonamides
  • Mechanism of Action Proto-oncogene protein b-raf inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Brain metastases; Malignant melanoma; Solid tumours

Most Recent Events

  • 20 Mar 2024 Pfizer terminates a phase I trial in Solid tumours and Brain metastases (Combination therapy, Late-stage disease, Metastatic disease) in USA, Israel and Canada (PO) (NCT04543188)
  • 03 Feb 2023 Discontinued - Phase-I for Brain metastases (Combination therapy, Late-stage disease, Metastatic disease) in USA (PO)
  • 03 Feb 2023 Discontinued - Phase-I for Brain metastases (Late-stage disease, Metastatic disease, Monotherapy) in USA (PO)

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