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CLN 049

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Drug Profile

CLN 049

Alternative Names: CLN-049

Latest Information Update: 11 Dec 2025

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At a glance

  • Originator German Cancer Research Center; University of Tubingen
  • Developer Cullinan Florentine; Cullinan Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants; Immunologic cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 08 Dec 2025 Updated efficacy and adverse events data from a phase-I trial in Acute myeloid leukemia and Myelodysplastic syndrome released by Cullinan Therapeutics
  • 01 Dec 2025 CLN 049 receives Fast Track designation for Acute myeloid leukaemia [IV] (Second-line therapy or greater) in USA
  • 03 Nov 2025 Efficacy and adverse events data from a phase I trial in Acute myeloid leukemia and Myelodysplastic syndrome released by Cullinan Therapeutics

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