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Tagtociclib - Pfizer

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Drug Profile

Tagtociclib - Pfizer

Alternative Names: PF-07104091; PF-4091; PF-91

Latest Information Update: 28 Aug 2025

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At a glance

  • Originator Pfizer
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Solid tumours
  • Phase I/II Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer

Most Recent Events

  • 17 Aug 2025 Pfizer plans a phase I trial in healthy volunteers in Netherlands (PO) in August 2025 (NCT07127770)
  • 13 Sep 2024 Efficacy, adverse events, pkarmacokinetics and pharmacodynamics data from a phase I/II trial in Solid tumours presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)
  • 13 Sep 2024 Pharmacodynamics data from a preclinical trial in Breast cancer presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)

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