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CT 388

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Drug Profile

CT 388

Alternative Names: CT-388; RG-6640; RO-7795068

Latest Information Update: 27 Mar 2026

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At a glance

  • Originator Carmot Therapeutics
  • Developer Carmot Therapeutics; Roche
  • Class Antihyperglycaemics; Hepatoprotectants; Obesity therapies; Peptides; Small molecules
  • Mechanism of Action Gastric inhibitory polypeptide receptor agonists; Glucagon-like peptide-1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Obesity; Type 2 diabetes mellitus
  • Discontinued Fatty liver; Non-alcoholic steatohepatitis

Most Recent Events

  • 27 Mar 2026 Roche initiates a phase I trial for Obesity (In volunteers) in Netherlands (SC)(EUCT2025-524856-73-00)(CTIS2025-524856-73-00)
  • 17 Mar 2026 Phase-III clinical trials in Obesity in USA (SC) (NCT07351058)
  • 17 Mar 2026 Phase-III clinical trials in Type 2 diabetes mellitus in USA (SC) (NCT07351058)

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