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Rhenium (186Re) obisbemeda - Plus Therapeutics

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Drug Profile

Rhenium (186Re) obisbemeda - Plus Therapeutics

Alternative Names: 186-Rheneium nanoliposome-Plus Therapeutics; 186RNL; Re-186; REYOBIQ™; Rhenium Re186 Obisbemeda; Rhenium-186 NanoLiposome; RNL™

Latest Information Update: 25 Aug 2025

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At a glance

  • Originator Plus Therapeutics
  • Class Antineoplastics; Heavy metals; Radioisotopes; Radiopharmaceuticals
  • Mechanism of Action Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Meningeal carcinomatosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Meningeal carcinomatosis
  • Phase II Glioma
  • No development reported Peritoneal cancer; Squamous cell cancer

Most Recent Events

  • 18 Aug 2025 Updated efficacy, pharmacokinetics and adverse events data from the phase I/II ReSPECT-LM trial in Meningeal carcinomatosis released by Plus Therapeutics
  • 11 Jul 2025 Plus Therapeutics plans a phase I ReSPECT-PBC trial for Ependymoma and Glioma (Second-line therapy or greater) in September 2025 (Parenteral) (NCT07061626)
  • 02 Jul 2025 Plus Therapeutics initiates a phase I trial for Meningeal carcinomatosis in USA (Intraventricular, Infusion) (NCT07098806)

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