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Rhenium (186Re) obisbemeda - Plus Therapeutics

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Drug Profile

Rhenium (186Re) obisbemeda - Plus Therapeutics

Alternative Names: 186-Rheneium nanoliposome-Plus Therapeutics; 186RNL; Re-186; REYOBIQ™; Rhenium Re186 Obisbemeda; Rhenium-186 NanoLiposome; RNL™

Latest Information Update: 30 Jun 2025

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At a glance

  • Originator Plus Therapeutics
  • Class Antineoplastics; Heavy metals; Radioisotopes; Radiopharmaceuticals
  • Mechanism of Action Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Meningeal carcinomatosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Glioma
  • Phase I/II Meningeal carcinomatosis
  • No development reported Peritoneal cancer; Squamous cell cancer

Most Recent Events

  • 25 Jun 2025 US FDA approves IND application for Rhenium (Re186) obisbemeda (REYOBIQ™) in Brain cancer (Late stage disease, Second line therapy or greater, In children, In adolescent, In adults)
  • 25 Jun 2025 Plus Therapeutics plans a phase I/IIa trial for Brain cancer (Late stage disease, Second line therapy or greater, In children, In adolescent, In adults)
  • 28 May 2025 No recent reports of development identified for preclinical development in Meningeal-carcinomatosis in USA (Intrathecal, Infusion)

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