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ARV 393

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Drug Profile

ARV 393

Alternative Names: ARV-393

Latest Information Update: 09 Dec 2025

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At a glance

  • Originator Arvinas
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto oncogene proteins c-bcl-6 degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Non-Hodgkin's lymphoma

Most Recent Events

  • 06 Dec 2025 Arvinas plans to initiate a phase I trial to evaluate ARV 393 plus Glofitamab (In combination therapy) for diffuse large B-cell lymphoma in 2026 (PO)
  • 06 Dec 2025 Pharmacodynamics data from a preclinical trial in Cancer released by Arvinas
  • 13 Jun 2025 Pharmacodynamics data from preclinical trial in Non-Hodgkin's lymphoma released by Arvinas

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