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ARV 806

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Drug Profile

ARV 806

Alternative Names: ARV-806; ARV-806 KRAS protein degraders - Arvinas; PROTAC KRAS G12D degrader; PROTAC®Y

Latest Information Update: 03 Nov 2025

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At a glance

  • Originator Arvinas
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein degraders; Proteolysis
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 24 Oct 2025 Pharmacodynamics data from a preclinical trial in cancer released by Arvinas
  • 22 Oct 2025 Pharmacodynamics data from a preclinical trial in Solid tumours presented at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)
  • 29 May 2025 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT07023731)

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