Drug Profile

DNL 921

Alternative Names: ATV Amyloid Beta - Denali Therapeutics; ATV-Amyloid-β - Denali Therapeutics; ATV-Aβ - Denali Therapeutics; DNL-921

Latest Information Update: 21 Jan 2026

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At a glance

Originator Denali Therapeutics Inc
Class Antibodies; Antidementias
Mechanism of Action Amyloid beta-protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Preclinical Alzheimer's disease

Most Recent Events

06 Jan 2026 Denali Therapeutics plans to initiate a phase I/Ib trial for Alzheimer’s disease in first half of 2026
28 Feb 2025 DNL 921 is still in preclinical trials for Alzheimer's disease in USA
28 Nov 2024 No recent reports of development identified for preclinical development in Alzheimer's-disease in USA (Parenteral)

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